Advertisement
Research Article

Functional Crosstalk between Type I and II Interferon through the Regulated Expression of STAT1

  • Daniel J. Gough,

    Affiliations: Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia, University of Melbourne, Melbourne, Victoria, Australia, New York University Langone Medical Center, New York, New York, United States of America

    X
  • Nicole L. Messina,

    Affiliations: Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia, University of Melbourne, Melbourne, Victoria, Australia

    X
  • Linda Hii,

    Affiliations: Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia, University of Melbourne, Melbourne, Victoria, Australia

    X
  • Jodee A. Gould,

    Affiliation: Centre for Innate Immunity and Infectious Disease, Monash Institute of Medical Research, Monash University, Melbourne, Victoria, Australia

    X
  • Kanaga Sabapathy,

    Affiliation: National Cancer Centre, Singapore, Singapore

    X
  • Ashley P. S. Robertson,

    Affiliations: Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia, University of Melbourne, Melbourne, Victoria, Australia

    X
  • Joseph A. Trapani,

    Affiliations: Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia, University of Melbourne, Melbourne, Victoria, Australia

    X
  • David E. Levy,

    Affiliation: New York University Langone Medical Center, New York, New York, United States of America

    X
  • Paul J. Hertzog,

    Affiliation: Centre for Innate Immunity and Infectious Disease, Monash Institute of Medical Research, Monash University, Melbourne, Victoria, Australia

    X
  • Christopher J. P. Clarke mail,

    chris.clarke@petermac.org (CJPC); ricky.johnstone@petermac.org (RWJ)

    Affiliations: Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia, University of Melbourne, Melbourne, Victoria, Australia

    X
  • Ricky W. Johnstone mail

    chris.clarke@petermac.org (CJPC); ricky.johnstone@petermac.org (RWJ)

    Affiliations: Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia, University of Melbourne, Melbourne, Victoria, Australia

    X
  • Published: April 27, 2010
  • DOI: 10.1371/journal.pbio.1000361

Reader Comments (1)

Post a new comment on this article

Incorrect

Posted by pavelkovarik on 12 May 2010 at 20:23 GMT

In addition, STAT1 proteins are phosphorylated on serine 727 prior to nuclear translocation which is essential for their full transcriptional activity [16].
http://plosbiology.org/article/info:doi/10.1371/journal.pbio.1000361#article1.body1.sec1.p3

The reference 16 shows that IFN-induced S727 phosphorylation of Stat1 occurs after nuclear translocation and only on chromatin-bound Stat1. That is, the reference 16 is not correctly described.

No competing interests declared.