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Research Article

Coordinated Movement of Cytoplasmic and Transmembrane Domains of RyR1 upon Gating

  • Montserrat Samsó mail,

    To whom correspondence should be addressed. E-mail: msamso@zeus.bwh.harvard.edu

    Affiliation: Division of Anesthesia Research, Department of Anesthesia, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Wei Feng,

    Affiliation: Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, Davis, California, United States of America

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  • Isaac N Pessah,

    Affiliation: Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, Davis, California, United States of America

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  • P. D Allen

    Affiliation: Division of Anesthesia Research, Department of Anesthesia, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Published: April 14, 2009
  • DOI: 10.1371/journal.pbio.1000085

Reader Comments (2)

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On the availability of cryoEM data

Posted by FilipVanPetegem on 20 May 2010 at 00:45 GMT

The data discussed in this publication tries to answer one of the most important questions in ryanodine receptor gating: what motions does the channel undergoe and how does the allosteric coupling between the cytoplasmic domains and the transmembrane region work?

In this respect, it is very disappointing to see that the corresponding data (the cryoEM maps of RyR1 in the open and closed states) have been 'on hold' for more than a year in the EMDB. Not releasing these data is obstructing scientific progress in the field, delaying new insights that can be gained, and thus delaying new future therapies that would benefit from an increased understanding of RyR function.

On behalf of many people in the RyR community, I urge the authors to set the right example in the cryoEM community: release the corresponding maps and let science progress.

Sincerely,

Filip Van Petegem

No competing interests declared.