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Research Article

Transient Neuronal Populations Are Required to Guide Callosal Axons: A Role for Semaphorin 3C

  • Mathieu Niquille equal contributor,

    equal contributor Contributed equally to this work with: Mathieu Niquille, Sonia Garel, Fanny Mann

    Affiliation: Department of Cellular Biology and Morphology, University of Lausanne, Switzerland

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  • Sonia Garel equal contributor,

    equal contributor Contributed equally to this work with: Mathieu Niquille, Sonia Garel, Fanny Mann

    Affiliation: Inserm, U784, Ecole Normale Supérieure, Paris, France

    X
  • Fanny Mann equal contributor,

    equal contributor Contributed equally to this work with: Mathieu Niquille, Sonia Garel, Fanny Mann

    Affiliation: CNRS, UMR 6216, Developmental Biology Institute of Marseille Luminy, Université de la Méditerranée, Marseille, France

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  • Jean-Pierre Hornung,

    Affiliation: Department of Cellular Biology and Morphology, University of Lausanne, Switzerland

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  • Belkacem Otsmane,

    Affiliation: CNRS, UMR 6216, Developmental Biology Institute of Marseille Luminy, Université de la Méditerranée, Marseille, France

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  • Sébastien Chevalley,

    Affiliation: Department of Cellular Biology and Morphology, University of Lausanne, Switzerland

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  • Carlos Parras,

    Affiliation: Division of Molecular Neurobiology, National Institute for Medical Research, Mill Hill, London, United Kingdom

    Current address: Laboratoire de Biologie des Interactions Neurones/Glie Inserm, U-711, Hôpital de la Salpêtrière, Paris, France

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  • Francois Guillemot,

    Affiliation: Division of Molecular Neurobiology, National Institute for Medical Research, Mill Hill, London, United Kingdom

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  • Patricia Gaspar,

    Affiliation: Inserm, U839, Institut du Fer à Moulin, Paris, France

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  • Yuchio Yanagawa,

    Affiliations: Department of Genetic and Behavioral Neuroscience, Gunma University Graduate School of Medicine, Maebashi City, Gunma, Japan, Solution Oriented Research for Science and Technology (SORST), Japan Science and Technology Agency(JST), Saitama, Japan

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  • Cécile Lebrand mail

    cecile.lebrand@unil.ch

    Affiliation: Department of Cellular Biology and Morphology, University of Lausanne, Switzerland

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  • Published: October 27, 2009
  • DOI: 10.1371/journal.pbio.1000230

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Traduction française de l'abstract/ French Translation of the Abstract

Posted by plosbiology on 03 Dec 2009 at 11:43 GMT

The corpus callosum (CC) is the main pathway responsible for interhemispheric communication. CC agenesis is associated with numerous human pathologies, suggesting that a range of developmental defects can result in abnormalities in this structure. Midline glial cells are known to play a role in CC development, but we here show that two transient populations of midline neurons also make major contributions to the formation of this commissure. We report that these two neuronal populations enter the CC midline prior to the arrival of callosal pioneer axons. Using a combination of mutant analysis and in vitro assays, we demonstrate that CC neurons are necessary for normal callosal axon navigation. They exert an attractive influence on callosal axons, in part via Semaphorin 3C and its receptor Neuropilin-1. By revealing a novel and essential role for these neuronal populations in the pathfinding of a major cerebral commissure, our study brings new perspectives to pathophysiological mechanisms altering CC formation.
http://plosbiology.org/article/info:doi/10.1371/journal.pbio.1000230#article1.front1.article-meta1.abstract2.p1

Traduction française de l'abstract disponible ici: http://www.plosbiology.org/attachments/pbio.1000230.french.pdf

French translation of the abstract available here: http://www.plosbiology.org/attachments/pbio.1000230.french.pdf


Translation by Sébastien D. Langlois. The accuracy of this translation has been confirmed by Cécile Lebrand.

No competing interests declared.