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Research Article

Gut Microbiota Is a Key Modulator of Insulin Resistance in TLR 2 Knockout Mice

  • Andréa M. Caricilli,

    Affiliation: Department of Internal Medicine, State University of Campinas, Campinas, Brazil

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  • Paty K. Picardi,

    Affiliation: Department of Internal Medicine, State University of Campinas, Campinas, Brazil

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  • Lélia L. de Abreu,

    Affiliation: Department of Nursing, State University of Campinas, Campinas, Brazil

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  • Mirian Ueno,

    Affiliation: Department of Internal Medicine, State University of Campinas, Campinas, Brazil

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  • Patrícia O. Prada,

    Affiliation: Department of Internal Medicine, State University of Campinas, Campinas, Brazil

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  • Eduardo R. Ropelle,

    Affiliation: Department of Internal Medicine, State University of Campinas, Campinas, Brazil

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  • Sandro Massao Hirabara,

    Affiliation: Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil

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  • Ângela Castoldi,

    Affiliation: Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil

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  • Pedro Vieira,

    Affiliation: Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil

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  • Niels O. S. Camara,

    Affiliation: Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil

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  • Rui Curi,

    Affiliation: Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil

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  • José B. Carvalheira,

    Affiliation: Department of Internal Medicine, State University of Campinas, Campinas, Brazil

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  • Mário J. A. Saad mail

    msaad@fcm.unicamp.br

    Affiliation: Department of Internal Medicine, State University of Campinas, Campinas, Brazil

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  • Published: December 06, 2011
  • DOI: 10.1371/journal.pbio.1001212

Reader Comments (4)

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Metabolic syndrome & PCOS

Posted by LBC2000 on 10 Jan 2012 at 20:34 GMT

This study is very interesting. I suffer from insulin resistance, thus have "metabolic syndrome," but since I also exhibit other female only symptoms, my doctors have classified it as polycystic ovarian syndrome. But, it's the same thing as Syndrome X. I'm not a scientist, so I only understand the outlying information, but what can be done in humans to reverse insulin resistance? Would something like a stool transplant (injecting healthy stool into an insulin resistant person's gut) change the bacterial profile of the insulin resistant to healthy? I've struggled for more than 10 years with this ... so I'm really happy to know there are scientists out there working on the problem!

No competing interests declared.