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Animal Defenses against Infectious Agents: Is Damage Control More Important Than Pathogen Control

  • Andrew F Read mail,

    To whom correspondence should be addressed. E-mail: a.read@psu.edu

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  • Andrea L Graham,
  • Lars Råberg
  • Published: December 23, 2008
  • DOI: 10.1371/journal.pbio.1000004

Reader Comments (2)

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Sickle cell is a tolerance, not resistance factor

Posted by dtae on 05 Jan 2011 at 17:57 GMT

unlike sickle cell anaemia in humans, which is a classical resistance factor because it reduces malaria parasite densities
http://plosbiology.org/article/info:doi/10.1371/journal.pbio.1000004#article1.body1.sec3.p1

Contrary to popular belief, sickle cell appears to be a tolerance factor to infection more than a resistance factor from infection. That is, it tends to reduce the severity of symptoms more than reduce actual parasite numbers.

See:
Wellems TE, Hayton K, and Fairhurst RM. 2009. The impact of malaria parasitism: from corpuscles to communities. J Clin Invest 119(9):2496-2505.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2735907/

No competing interests declared.