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Animal Defenses against Infectious Agents: Is Damage Control More Important Than Pathogen Control

  • Andrew F Read mail,

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  • Andrea L Graham,
  • Lars Råberg
  • Published: December 23, 2008
  • DOI: 10.1371/journal.pbio.1000004

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Sickle cell is a tolerance, not resistance factor

Posted by dtae on 05 Jan 2011 at 17:57 GMT

unlike sickle cell anaemia in humans, which is a classical resistance factor because it reduces malaria parasite densities

Contrary to popular belief, sickle cell appears to be a tolerance factor to infection more than a resistance factor from infection. That is, it tends to reduce the severity of symptoms more than reduce actual parasite numbers.

Wellems TE, Hayton K, and Fairhurst RM. 2009. The impact of malaria parasitism: from corpuscles to communities. J Clin Invest 119(9):2496-2505.

No competing interests declared.