The detailed structure of a membrane-embedded prenyltransferase from the UbiA family by Hua Huang, Ming Zhou and colleagues reveals the architecture of the active site and suggests a possible mechanism by which it adds hydrophobic polyprenyl groups to its substrates.
A new study by Krishnakumar Kizhatil, Simon John and colleagues finds that Schlemm's Canal, a draining vessel in the eye, arises via a novel hybrid process of vascular development and is important for understanding ocular fluid homeostasis and glaucoma. Read more in the Synopsis.
Borislav Dejanovic, Guenter Schwarz and colleagues discover that gephyrin – the principal scaffolding protein at inhibitory synapses – needs to be modified with the hydrophobic palmitoyl group in order to cluster and to assemble functional synapses.
New Research by Noriaki Sasai, Eva Kutejova and James Briscoe demonstrates the importance of integrating FGF signalling with two perpendicular signalling pathways (Shh and BMP) to specify important cell types (Floor Plate and Neural Crest, respectively) during the development of the neural tube.