Moses Kasembeli, David Tweardy and colleagues have discovered that the folding and function of the infamous cancer- and inflammation-related signaling molecule Stat3 are regulated by its interaction with the chaperonin TRiC; manipulation of this interaction could be explored for therapeutic purposes.
Susan Mashiyama, Patricia Babbitt and colleagues use a global network of more than 13000 cytosolic glutathione S-transferases to examine their sequence-structure-function relationships and to prioritise them for experimental confirmation of enzymatic activity (82 members) and determination of crystal structures (27 members). Read more in this Synopsis.
This paper, by Michael Harfoot, Drew Purves and colleagues, presents the first mathematical model that attempts to represent the biology and behavior of all individual organisms globally, taking us a step closer to a holistic ecological and conservation science founded on mechanistic predictions.
Two independent studies, one by Ron Anafi, John Hogenesch and colleagues and another by Akihiro Goriki, Toru Takumi and co-authors, converge on CHRONO as a gene that modulates the activity of circadian transcription factors and alters circadian behavior in mice. Read more in the Synopsis.
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